Yes, it can happen.
The meaning behind a search term can change depending on current events and cultural shifts.
In some cases, events in a given month might create new topic connections to a search term, thus altering its meaning. If you notice this happening, one way to get a better understanding of culture is to look at periods ending two or three months prior to the original search. This can help provide a better overview or even indicate an impending trend.
E.g. If you may notice differences if you run the same search for a year period ending in December 2020 and November 2020 (searches must be one-year minimum to calculate cultural maturity). Trying different end months, you'll be able to identify and isolate whether a particular month experienced an out-of-the-ordinary spike in cultural activity.
You may then choose to either further explore or ignore/discount that spike in your analysis.